Methadone Withdrawal and Detox

Methadone withdrawal symptoms are usually moderate in severity and last for several weeks. Medical detox can reduce withdrawal symptoms and make the process safer for the user.

What is Methadone Withdrawal?

Depression is a common withdrawal symptom.Methadone can be extremely physically addictive, especially when taken in high doses. The drug is commonly used to treat opiate addictions, leading some users to trade one addiction for another. If taken frequently, tolerance to methadone can develop quickly, which means the user will require more of the drug to achieve the desired effects.

Once the body becomes reliant on methadone to function normally, a dependence has developed. Those with a dependence on methadone will experience withdrawal symptoms if they quit taking the drug.

Withdrawal happens because the body has to relearn how to function without methadone in its system. While the body tries to reestablish normal functions, uncomfortable withdrawal symptoms occur, which can make recovery difficult.

Because the withdrawal process can cause adverse symptoms, methadone users are advised to detox in a medical environment. Most inpatient and outpatient treatment programs offer medical detox, which can help reduce the severity of methadone withdrawal symptoms.

The withdrawal process is different for everyone. The symptoms and duration of withdrawal will vary depending on the severity and length of the user’s addiction. A user’s body chemistry and tolerance will also affect their symptoms and how long the withdrawal process takes.

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Symptoms of Withdrawal

Symptoms of withdrawal from methadone are similar to those of other opiates, such as heroin and morphine, but are typically less intense. Methadone withdrawal symptoms are usually moderate and flu-like.

Common symptoms include:

  • Chills
  • Fever
  • Anxiety
  • Muscle aches and pains
  • Nausea or vomiting
  • Sweating
  • Rapid heartbeat
  • Stomach cramps
  • Irritability
  • Paranoia
  • Diarrhea
  • Cravings
  • Insomnia
  • Hallucinations
  • Depression

Those with more severe methadone addictions will likely experience more serious withdrawal symptoms. If the user is addicted to multiple substances, the withdrawal process may be longer and more intense.

Quitting “cold turkey” will cause more severe withdrawal symptoms. Doctors usually recommend tapering off use of methadone to make the withdrawal process more bearable.

“I was withdrawing cold turkey, by choice, from methadone on my parents’ couch in Daytona Beach, 250 miles away from my clinic and conspiring ways to teleport the pink syrup, realizing what happened to me. I used to be a heroin addict, then I was a methadone addict. I sank my sweaty, twitching body into the cushions. Seventy two hours for the stuff to get out of my body, and a lifetime of convincing myself the grass isn’t greener on the methadone side.”

- Jade Ryan, methadone addict working towards recovery, xoJane.com, 2014
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    Duration of Withdrawal

    Symptoms typically present within 24 hours of the user’s last dose. However, it can take anywhere between 15 and 60 hours for methadone to be out of a user’s system. For some people, it may take several days for withdrawal to begin.

    Symptoms of withdrawal from methadone usually last three to six weeks, but the process can take longer for those with severe addictions.


    The first seven to 10 days tend to be the worst, with flu-like physical symptoms and distressing psychological symptoms, such as anxiety and paranoia. Over the next several weeks, withdrawal symptoms will fade.

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    Methadone Withdrawal Timeline

    First 24 hoursSymptoms of withdrawal usually begin within a day of a user’s last dose of methadone. Physical symptoms, such as chills, fever, rapid heartbeat, and muscle aches, will begin during this time.
    Days 2-10Over the next week or so, methadone cravings will be strong. Users may face paranoia, hallucinations and insomnia, as well as irritability and anxiety. Flu-like physical symptoms will persist, but should improve after about a week.
    Days 11-21At this point, most physical symptoms should have begun to fade. Users may still feel strong drug cravings and depression may set in. Depression can become severe and some patients may have difficulty feeling pleasure or getting motivated.
    Days 22+If any symptoms remain, they should be very mild. Depression may still be intermittent for several weeks as the body readjusts to life without methadone.

    Methadone Detox

    Methadone detox is safest and most efficient when completed in a drug treatment facility or hospital.

    Methadone users should always detox under the supervision of a doctor to prevent withdrawal symptoms from becoming life-threatening.

    Most medical detoxes provide a tapering off of the drug, or reducing the user’s dosage over a period of weeks. This method reduces the severity of withdrawal symptoms and is usually recommended over quitting cold turkey. However, tapering off the drug takes longer.

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    Treatment for Methadone Addiction

    Drug treatment centers utilize the expertise of physicians and therapists to develop a personalized treatment plan for each patient. An inpatient treatment program will give moderate to severe methadone addicts their best chance at a successful recovery. Outpatient treatment is also an option for those with mild methadone addictions.

    If you or someone you love is struggling with a methadone addiction, you don’t have to suffer alone any longer. Please contact us today for help finding a drug treatment center that fits your needs.

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