Disulfiram

The Food and Drug Administration (FDA) currently approves three medications for alcoholism. The oldest and historically most commonly prescribed is Disulfiram, also commonly known by the brand name Antabuse.

Disulfiram for Alcoholism Treatment

Diagram of the Chemical Formula for Disulfiram

Disulfiram (tetraethylthiuram disulfide or Antabuse) has been prescribed for the treatment of alcohol use disorders (AUDs) in the United States for more than 65 years and is currently used by more than 200,000 Americans. Disulfiram works by interfering with the body’s digestion and absorption of alcohol, creating a series of highly unpleasant reactions in the process. When an individual who is taking Disulfiram consumes alcohol they will begin to experience:

  • Flushing of the skin
  • Nausea and vomiting (sometimes violent)
  • Headaches
  • Sweating
  • Weakness
  • Higher blood pressure

These effects make it extremely unpleasant for someone who is taking Disulfiram to consume alcohol. Disulfiram therefore acts as a deterrent to alcohol use. Although the drug does not actively reduce alcohol cravings, which are still present, many individuals are sufficiently discouraged from alcohol use that they find it easier to remain sober.

Disulfiram’s method of action is to block the functioning of alcohol dehydrogenase, the enzyme that breaks down ethanol (drinking alcohol) in the liver. This leads to an increased concentration of acetaldehyde, which in turn causes the discomfort. The disulfiram-ethanol reaction (DER) can be very severe, and in rare cases even fatal. Modern day doses are much lower than doses from decades ago, and severe reactions are much rarer as a result.

Questions about treatment?

Get confidential help 24/7. Call now for:

  • Access to top treatment centers
  • Caring, supportive guidance
  • Financial assistance options
(855) 400-5261

Proper Use of Disulfiram

Disulfiram is a prescription medication and should only be taken under the supervision of a physician. Disulfiram should only be taken after the patient has gone through the initial period of withdrawal and detox, has completely abstinence from alcohol for at least 12 hours, and has a blood alcohol level of zero. This is especially important because the DER can begin as early as 10 to 30 minutes after ingestion of Disulfiram. The average initial dose of Disulfiram is 250 milligrams once a day for 1-2 weeks, with the average maintenance dose of 250 milligrams a day thereafter. However, the daily dosage can range from 125 to 500 milligrams a day.

A Young Woman Suffering Nausea And Other Effects Of Using Alcohol While Taking Disulfiram

Disulfiram should only be taken after the patient has been sufficiently educated about its impacts. Some physicians maintain that patients must have a reaction in front of them to be sufficiently educated, but this is no longer commonplace. Disulfiram should only be administered after the physician has performed a physical exam, baseline liver and kidney function tests, pregnancy tests (for women), and electrocardiogram (if the patient has a history of cardiovascular disease).

Some studies indicate that Disulfiram is most effective when taken in conjunction with other alcoholism medications, especially Acamprosate (Campral). It is widely accepted that Disulfiram is most effective for patients who are truly committed to their sobriety, and that it is ideally taken under supervision to ensure the patient is compliant with treatment. Some individuals may be resistant to the impact of the DER and may not feel its effects.

If the patient misses a dose of Disulfiram and it is not close to the next scheduled dose, it may be ok to take it. If it is close to the time of the next scheduled dose, it is better to skip the dose. Patients should never double up on a dose of Disulfiram.

Special care must be taken around products that contain alcohol. Disulfiram might create reactions when patients inhale fumes of paint, paint thinner, varnish, shellac, and similar products. Similarly, Disulfiram may cause reactions when patients’ skin comes into contact with aftershave lotions, colognes, and rubbing alcohol.

Although it is a highly effective deterrent from alcohol use, Disulfiram alone is generally not sufficient to treat alcoholism. Disulfiram should be a part of a larger treatment regimen including rehab, therapy, counseling, and 12-step programs.

Background image

Ready to get help?

Don’t waste another second. Enter your number to receive a call from a compassionate treatment expert.
Don’t waste another second. Call now to speak with a compassionate treatment expert.

    Side Effects of Disulfiram

    Disulfiram has been extensively used for more than 65 years with great success. One of the primary reasons is that the medication has comparatively few and minor side effects. Generally, these side effects will lessen or even disappear within a few weeks. However, some Disulfiram side effects can be quite serious, potentially even fatal, so it important for anyone taking this drug to be vigilant.

    Some of the most common side effects of Disulfiram include:

    • Drowsiness
    • Metallic taste
    • Headaches
    • Sexual dysfunction
    • Acne
    See how Jerry
    overcame his
    addiction.
    Jerry Lawson sitting in a chair

    Some of the less common, but more serious side effects of Disulfiram include:

    • Liver toxicity, disease, and failure
    • Hepatitis
    • Optic neuritis
    • Peripheral neuritis and neuropathy
    • Psychosis
    • Delirium
    • Hypersensitivity to the drug
    • Reactions with other medications

    Benefits of Disulfiram

    • Helps alcoholics stop drinking by creating adverse reactions when they drink
    • Comparatively few side effects present themselves
    • Many years of successful use means that this drug is very well-studied and documented, with minimal risk
    • Will cause adverse impacts when only a miniscule amount of alcohol is consumed, making it a successful deterrent for even mild drinking
    Get started on the road to recovery.
    sidebar_cta_img

    Disulfiram Statistics

    50

    percent

    Incorporating disulfiram into an alcohol recovery treatment program produced an abstinence rate of more than 50 percent.

    20

    months

    Individuals who have taken disulfiram for an average of 20 months have showed the highest rates of abstinence.

    18

    million

    An estimated 18 million Americans suffer from an alcohol use disorder, including alcohol dependence and alcohol abuse.

    Find Treatment Now

    Disulfiram has a long history of success in treating alcoholism when taken along other treatment methods. However, It should only be taken after initial withdrawal and detox have been completed, which can be dangerous, even fatal. If you or a loved one need help overcoming an addiction to alcohol, you can’t afford to wait. Contact a treatment specialist today to find a rehab.

    Get help today

    Don't go through the process of recovery alone. Get in touch with someone who can help.

      Get 24/7 help now. All calls free and confidential.

      (855) 400-5261

      Take control of your life

      Our treatment specialists offer 24/7 assistance.

      • Access to top treatment centers
      • Caring, supportive guidance
      • Financial assistance options

      Call now:

      (855) 400-5261

      OR

      Have us call you:

        Where do calls go?

        Callers will be routed to:

        • Delphi Behavioral Health Group

        A treatment facility paid to have their center promoted here. To learn more about how to be featured in a paid listing, click here.